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April 19, 2026ImmunoOpen Access

Neuroimmune Amplification and Resolution of Chronic Pain: A Systematically Searched Narrative Review

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Authors

KGKeren Grinberg

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Overview

This narrative review explores how immune functions influence chronic pain, suggesting implications for treatment strategies.

Key Points

  • This review aims to explore the neuroimmune mechanisms contributing to chronic pain and the processes involved in pain resolution.
  • Conducted a structured search of PubMed/MEDLINE and other databases.
  • Included high-impact reviews, meta-analyses, and mechanistic studies on chronic pain.
  • Synthesized data on biomarkers related to low back pain, neck pain, and fibromyalgia.
  • Identified immune mediators play a crucial role in amplifying pain responses.
  • Found evidence of bidirectional immune processes that assist in pain resolution.
  • Highlighted the need for tailored interventions based on mechanistic insights into chronic pain.

Cite This Study

Keren Grinberg (2026) studied this question.

synapsesocial.com/papers/69e47220010ef96374d8e3cdhttps://doi.org/10.3390/immuno6020028
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