Unified, Catalyst-Controlled, Bioinspired Total Synthesis of Dimeric Piperine Alkaloids in Batch and Flow †

Mohammed Latrache; Amina Sesay; Samuel Oger; Mireia Benito Montaner; Jinlei Zhang; Mellah Mohamed; Erwan Poupon; Stephen Timothy Hilton; Stellios Arseniyadis; Laurent Evanno

doi:10.1039/d6cc01304j

January 1, 2026Chemical CommunicationsOpen Access

Unified, Catalyst-Controlled, Bioinspired Total Synthesis of Dimeric Piperine Alkaloids in Batch and Flow †

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Key Points

The aim is to achieve a total synthesis of dimeric piperine alkaloids using a catalyst-controlled approach.
Utilized photocatalytic dimerization of piperine
Implemented selective [2+2] and [4+2] cycloadditions
Conducted synthesis in both batch and flow systems.
Successfully synthesized nigramide R, chabamide, and dipiperamide F and G
Demonstrated efficiency of catalyst-controlled dimerization
Highlighted the versatility of the bioinspired approach.

Implication

Demonstrates the total synthesis of alkaloids in batch and flow, suggesting a new pathway for drug development.

Abstract

We report a unified, bioinspired total synthesis of nigramide R, chabamide, and dipiperamide F and G enabled by catalyst-controlled photocatalytic dimerization of piperine. Selective [2+2] or [4+2] cycloadditions proceed in...

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Cite This Study

Latrache et al. (2026) studied this question.

synapsesocial.com/papers/69e47220010ef96374d8e443 https://doi.org/10.1039/d6cc01304j

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Unified, Catalyst-Controlled, Bioinspired Total Synthesis of Dimeric Piperine Alkaloids in Batch and Flow †

Key Points

Implication

Abstract

Discussion

Cite This Study

Unified, Catalyst-Controlled, Bioinspired Total Synthesis of Dimeric Piperine Alkaloids in Batch and Flow †

Key Points

Implication

Abstract

Discussion

Cite This Study

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