PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 19, 2026Periodontology 20000 citationsOpen Access

Systemic and local antibiotics in the management of peri‐implantitis: A systematic review and network meta‐analysis

View Full Paper
JSJamil A. ShibliVMVittório MoraschiniKCKhalila C Cotrim

Key Points

  • The aim is to determine the effectiveness of systemic and local antibiotics in managing peri-implantitis.
  • Conducted a systematic review and network meta-analysis of antibiotic treatments.
  • Evaluated various treatment combinations including metronidazole and amoxicillin.
  • Analyzed clinical and microbiological outcomes related to antibiotic use.
  • Metronidazole with non-surgical treatment was identified as highly effective.
  • Combined use of amoxicillin and metronidazole in open flap debridement showed improved results.
  • Local antibiotic applications were less effective than systemic treatments in improving clinical parameters.

Abstract

The most effective treatments were metronidazole as adjunct to non-surgical treatment and combined with amoxicillin adjuncts to open flap debridement. While local antibiotic applications also enhance clinical parameters, they appear less effective than systemic regimens. Future well-designed clinical trials focusing on microbiological outcomes and standardized protocols are warranted to optimize periimplantitis management strategies.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Shibli et al. (2026) studied this question.

synapsesocial.com/papers/69e47250010ef96374d8e6dehttps://doi.org/10.1111/prd.70029
Ask AI
Helpful
Bookmark
Share
View Full Paper