PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 19, 2026Prenatal Diagnosis0 citationsOpen Access

Free Fetal DNA Testing to Guide Early Intervention in the Management of the Kell Alloimmunized Pregnancy

View Full Paper
KMKenneth J. MoiseDell Children's Medical Center of Central TexasTTThomas TrevettSMStephanie MoenchDell Children's Medical Center of Central Texas

Key Points

  • This research examines the use of free fetal DNA testing to guide early interventions in Kell alloimmunized pregnancies.
  • Conducted tests to determine fetal red cell genotype using free fetal DNA.
  • Monitored middle cerebral artery peak systolic velocity in pregnancies at risk for alloimmunization.
  • Evaluated the need for intrauterine transfusions based on genotype results.
  • Free fetal DNA reliably identifies fetal red cell genotype.
  • Elevated peak systolic velocity may falsely appear during early second trimester.
  • Intrauterine transfusions are recommended primarily for documented positive fetal genotypes.

Abstract

Key Points Free fetal DNA can accurately be used to determine the fetal red cell genotype. A false positive elevation of the middle cerebral artery peak systolic velocity can occur in the early second trimester in a red cell alloimmunized pregnancy. In most cases, fetal intrauterine transfusions should be limited to pregnancies with a documented positive fetal genotype for the involved antigen.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Moise et al. (2026) studied this question.

synapsesocial.com/papers/69e47282010ef96374d8e7b3https://doi.org/10.1002/pd.70159
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cell-Free DNA Analysis for the Determination of Fetal Red Blood Cell Antigen Genotype in Individuals With Alloimmunized Pregnancies2024 · 25 citations
  2. 2Cell-free DNA analysis for the determination of fetal red blood cell antigen genotype in alloimmunized pregnancies2024
  3. 3Paternal and Fetal Genotyping in the Management of Alloimmunization in Pregnancy2024 · 15 citations
  4. 4Comment on “Diagnostic Accuracy of Cell-free DNA for the Determination of Fetal Red Blood Cell Antigen Genotype: A Systematic Review and Meta-analysis”2026
  5. 5Society for Maternal‐Fetal Medicine Statement: Evaluation and management of cell‐free DNA screening for fetal red cell antigen genotype in alloimmunized and non‐alloimmunized pregnancies2026