Free fetal DNA testing determines fetal red cell genotype, guiding management in alloimmunized pregnancies, indicating necessary interventions.
Key Points Free fetal DNA can accurately be used to determine the fetal red cell genotype. A false positive elevation of the middle cerebral artery peak systolic velocity can occur in the early second trimester in a red cell alloimmunized pregnancy. In most cases, fetal intrauterine transfusions should be limited to pregnancies with a documented positive fetal genotype for the involved antigen.
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Moise et al. (2026) studied this question.
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