Finds that prenatal IGF-1 treatment is ineffective and harmful in a rat model of cortical malformation, hinting at cautious application of such therapies.
Although IGF-1 has known neurotrophic properties, early and sustained exposure to the (1-3)IGF-1 analog did not ameliorate structural-, metabolic-, or seizure-related abnormalities and produced detrimental behavioral effects in this model of cortical malformation. These findings underscore the importance of developmental timing and molecular specificity when applying IGF-1-based interventions and caution against the assumption that earlier or prolonged treatment is necessarily beneficial in malformed cortical circuits.
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Lee et al. (2026) studied this question.
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