Tissue Accessibility as a Missing Determinant of Immunomodulatory and Platelet‐Rich Plasma Therapy Success in Infertility: A Conceptual Framework

Key Points

• The research aims to explore how tissue accessibility affects the success of immunomodulatory and platelet-rich plasma therapies in infertility.
• Analyzed the concept of tissue accessibility regarding immunomodulators and PRP growth factors.
• Discussed mechanisms of actions such as paracrine signaling and angiogenesis.
• Emphasized the need for pharmacokinetic studies to obtain drug concentration data in reproductive tissues.
• Found that tissue penetration of therapies may be less critical than previously thought.
• Indicated that immunomodulatory effects may operate mainly through systemic mechanisms.
• Suggested caution in clinical applications until more data on drug concentrations become available.