This study aimed to formulate, develop, and evaluate fast-dissolving tablets of bezafibrate using the solid dispersion method. The formulation process focused on enhancing the dissolution rate and bioavailability of bezafibrate, a poorly water-soluble drug. Precompression parameters such as thickness, diameter, hardness, friability, drug content, and weight variation were optimized to ensure the quality and uniformity of the tablets. In vitro evaluation involved assessing dispersion time, wetting time, and dissolution profiles over a three-month period to determine stability under different storage conditions. The findings suggest that the developed bezafibrate fast-dissolving tablets hold promise for improved drug delivery and patient compliance, offering valuable insights into their formulation and performance.
Dr. P. Perumal, S. Selvaraj*, K. Manimekala (Thu,) studied this question.