PulseExploreJournal ClubTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 19, 2026Cancer Research

Abstract LB127: Drivers and patterns of disease progression as a novel schema for risk stratification in metastatic non-small cell lung cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

GEGabriela R. EsnaolaMWMengru WangJIJeffrey Ishizuka

Discussion

Loading...

Member takes

Overview

Retrospective Study Assesses Survival Outcomes In Patients With Metastatic NSCLC, Highlighting Risk Factors.

Key Points

  • This research aims to identify the drivers and patterns of metastatic progression in non-small cell lung cancer, enhancing risk stratification.
  • Analyzed data from the Flatiron Health-Foundation Medicine Clinico-Genomic Database.
  • Compared patient, tumor, and treatment variables using chi-squared tests.
  • Estimated overall survival using the Kaplan Meier method and adjusted hazard ratios with Cox regression.
  • Employed Bernoulli mixture models to cluster patients by metastatic sites at first-line therapy.
  • Evaluated data for 10,571 patients with NSCLC.
  • Identified 8 clusters of metastatic sites, revealing that certain sites had worse overall survival.
  • Notably, patients with bone and adrenal metastases exhibited worse median overall survival than those with lung or brain metastases.
  • Certain genomic mutations were associated with specific metastatic sites, influencing survival outcomes.
  • Targeted therapy was linked to improved survival compared to other systemic therapies in specific metastatic clusters.

Cite This Study

Esnaola et al. (2026) studied this question.

synapsesocial.com/papers/69e4739a010ef96374d8f629https://doi.org/10.1158/1538-7445.am2026-lb127
View Full Paper
Ask AI
Bookmark
Share