Recent Advances in Catalytic Quadruple‐Cascade Reactions for the Construction of Structurally Complex Organic Molecules

Over the last three decades, developing efficient and selective catalytic strategies has remained a backbone of modern synthetic organic chemistry. In recent years, quadruple‐cascade catalytic methods, in which four new bonds are formed under one‐pot reaction conditions, have emerged as a powerful modern tool for directly constructing structurally complex organic molecules from simple, inexpensive, and readily available starting materials. These catalytic systems involve organocatalysis, transition‐metal catalysis, and photocatalysis to achieve good to excellent levels of chemo‐, regio‐, enantio‐, and stereoselectivity in a single‐step process. This review highlights recent advances in novel catalytic methods and understanding of cascade strategies, emphasizing reaction scope, operational simplicity, and step economy, offering a robust, green approach. Moreover, the described synthetic approach are used to access drugs, natural products, bioactive compounds, and optical or electronic materials. Moreover, current synthetic challenges and their potential in organic and medicinal chemistry through a sustainable cascade process.