Cross-species and cross-border spread of aph(3′)-ia -mediated neomycin resistance in Escherichia coli from animals: a genomic perspective

Key Points

• The research aims to understand how neomycin resistance spreads in E. coli from animals across borders.
• Conducted genomic analysis of E. coli strains from livestock in Europe.
• Examined the mobility of aph(3')-Ia resistance gene.
• Analyzed genetic contexts and plasmid backbones of resistance genes.
• Identified that aph(3')-Ia facilitates co-transfer of multiple resistance traits.
• Demonstrated significant genetic diversity in resistance gene contexts.
• Highlighted the role of plasmid backbones in the spread of resistance.