Key result
CFAE-guided ablation for chronic AF yields modest efficacy, requiring repeat procedures in ~40% of patients.
Why the study?
Radiofrequency ablation of chronic AF guided by complex fractionated atrial electrograms has modest short-term efficacy and often requires repeat procedures.
Does radiofrequency catheter ablation guided by complex fractionated atrial electrograms improve short-term efficacy in patients with chronic atrial fibrillation?
Does radiofrequency catheter ablation guided by complex fractionated atrial electrograms improve short-term efficacy in patients with chronic atrial fibrillation?
Radiofrequency ablation guided by complex fractionated atrial electrograms offers modest short-term efficacy for chronic AF, with over 40% of patients needing a repeat procedure.
Should not yet change ablation practice in chronic AF; leaves open the incremental benefit of CFAE guidance versus standard approaches.
Modest short-term efficacy is achievable with radiofrequency ablation of chronic AF guided by complex fractionated atrial electrograms, but only after a second ablation procedure in > 40% of patients. Rapid activity in the pulmonary veins and multiple macroreentrant circuits are common mechanisms of recurrent atrial arrhythmias.
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Oral et al. (2007) studied this question. Radiofrequency ablation of chronic AF guided by complex fractionated atrial electrograms yields modest short-term efficacy, but requires a second ablation procedure in >40% of patients.
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