⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 6, 2020Arthritis & RheumatologyOpen Access

Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling

Karsyn N. Bailey Jeffrey Nguyen Cristal S. Yee Neha S. Dole Alexis Dang Tamara Alliston

View Full Paper

Ask AI

Bookmark

Share

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Abstract

Our results provide new evidence that osteocytic TGFβ signaling is required for a mechanosensitive response to injury, and that osteocytes control SBP homeostasis to maintain cartilage health, identifying osteocytic TGFβ signaling as a novel therapeutic target for OA.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bailey et al. (2020) studied this question.

synapsesocial.com/papers/69e58000aec8584618dfe2b9 https://doi.org/10.1002/art.41548

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit kneeOriginal Research · 2003 · 36 citations
2Subchondral bone formation in arthrosis: Polychrome labeling studies in miceOriginal Research · 1988 · 32 citations
3Bone and cartilage changes following experimental varus or valgus tibial angulationOriginal Research · 1990 · 122 citations
4Loading‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage OsteoarthritisOriginal Research · 2017 · 69 citations
5Chondrocyte‐intrinsic Smad3 represses Runx2‐inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritisOriginal Research · 2012 · 142 citations
6Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and MiceOriginal Research · 2009 · 304 citations
7Induction of an osteoarthritis‐like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic miceOriginal Research · 2008 · 119 citations
8Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on BoneOriginal Research · 2009 · 179 citations
9Predicting Inactive Disease in Juvenile Idiopathic Arthritis: A Dynamic Machine Learning ApproachArthritis & Rheumatology · 2026
10Hypogammaglobulinemia in Patients With Inflammatory Rheumatic Diseases Treated With IL-6 Receptor Inhibitors: A Retrospective Comparative Cohort Study.Arthritis & Rheumatology · 2026

More from Arthritis & Rheumatology

More from University of California, San Francisco

More from San Francisco VA Medical Center

More from California State University, Long Beach

More from California State University System