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January 8, 2020Genome MedicineOpen Access

Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

Kara A. Moser Elliott F. Drábek Ankit Dwivedi Emily M. Stucke Jonathan Crabtree Antoine Dara Zalak Shah Matthew Adams Tao Li Priscila T. Rodrigues Sergey Koren Adam M. Phillippy James B. Munro Amed Ouattara Benjamin C. Sparklin Julie C. Dunning Hotopp Kirsten E. Lyke Lisa Sadzewicz Luke J. Tallon Michele Spring Krisada Jongsakul Chanthap Lon David Saunders Marcelo U. Ferreira Myaing M. Nyunt Miriam K. Laufer Mark A. Travassos Robert W. Sauerwein Shannon Takala‐Harrison Claire M. Fraser B. Kim Lee Sim Stephen L. Hoffman Christopher V. Plowe Joana C. Silva

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Abstract

These results will assist in the interpretation of vaccine efficacy of whole-organism vaccines against homologous and heterologous CHMI.

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Moser et al. (2020) studied this question.

synapsesocial.com/papers/69e5b5e03320d84e697f89a2 https://doi.org/10.1186/s13073-019-0708-9

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Development of a metabolically active, non-replicating sporozoite vaccine to preventPlasmodium falciparummalariaLate-Phase Clinical Trial · 2010 · 297 citations
2Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 <sup>+</sup> T Cell ImmunityOriginal Research · 2011 · 533 citations
3Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite VaccineOriginal Research · 2013 · 765 citations
4Protection against Plasmodium falciparum malaria by PfSPZ VaccineOriginal Research · 2017 · 240 citations
5Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infectionOriginal Research · 2017 · 243 citations

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