Systematic review finds IM midazolam more effective than IN midazolam in controlling seizures in children, suggesting it as a top choice in emergencies.
Among pediatric patients with acute seizures managed in settings where IV access is not established, particularly the prehospital environment, IM midazolam was associated with more rapid seizure termination and lower rescue therapy use than IN midazolam and represents a reasonable first-line option in these settings.
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Mohnkern et al. (2026) studied this question.
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