Key result
Valve-sparing aortic root surgery in Marfan syndrome linked to decreased distensibility and increased wall shear stress.
Why the study?
Implantation of a non-compliant synthetic graft during aortic root surgery in Marfan syndrome may alter aortic biomechanics and hemodynamics, potentially contributing to late distal aortic complications.
Does valve-sparing aortic root surgery alter aortic biomechanics and hemodynamics in patients with Marfan syndrome?
Observational (n=3)
Does valve-sparing aortic root surgery alter aortic biomechanics and hemodynamics in patients with Marfan syndrome?
Valve-sparing aortic root surgery in Marfan syndrome predictably alters ascending aortic biomechanics and hemodynamics, increasing rigidity and wall shear stress, which may have implications for late distal aortic complications.
Prompts closer distal aortic monitoring in MFS after root surgery; leaves open contribution of synthetic grafts to late distal events.
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Bosshardt et al. (2026) conducted an observational in Marfan syndrome (n=3). Valve-sparing aortic root surgery vs. Preoperative baseline was evaluated on Changes in aortic motion and flow characteristics. Valve-sparing aortic root surgery in Marfan syndrome predictably decreased ascending aortic 3D distensibility in all 3 patients (e.g., 4.1 to 1.7 in patient 1) and increased wall shear stress.
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