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Experiments demonstrate a neuroprotective effect of HLA alleles against alpha-synuclein pathology in Parkinson disease, suggesting potential genetic factors in disease vulnerability.
Altogether, our findings provide the first experimental evidence of the genetic association between the HLA locus and PD susceptibility and support a neuroprotective function for the HLA-DRB1*04:01 allele against alpha-synuclein pathology.
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Carver et al. (2026) studied this question.
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