A Case of Progressive Radiation-Induced Cerebrovascular Disease in an Adult Survivor of Childhood Cranial Irradiation

January 1, 2026NosotchuOpen Access

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Key Points

To describe progressive cerebrovascular disease in an adult who received cranial irradiation as a child.
Case study of a 51-year-old male who underwent whole-brain irradiation at age 8 for germinoma.
Imaging assessments to evaluate cerebrovascular changes including stenosis, microbleeds, and aneurysm formation.
Longitudinal observation of cerebrovascular complications emerging 20 years post-treatment.
The patient experienced repeated lacunar infarctions, intracerebral hemorrhage, and developed an internal carotid artery aneurysm.
Imaging revealed sustained cerebrovascular damage including arterial stenosis and white matter changes over 40 years.
Cumulative microbleeds were noted as independent predictors of stroke, emphasizing risks associated with high-dose irradiation.

Case report reveals ongoing cerebrovascular complications decades after cranial radiation in adulthood, suggesting long-term monitoring is crucial.

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Matsumoto et al. (2026) studied this question.

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