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April 20, 2026EngineeringOpen Access

A Stretchable Optogenetic Probe for Wireless Control of Bladder Nociception

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Authors

JJJanghoon JooHAHannah A. AndersonWKWoo Seok Kim

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Overview

Advance in wireless optogenetic systems modulates bladder nociception through a fully implantable probe, highlighting its potential.

Key Points

  • The aim is to create a wireless optogenetic system for precise control of bladder nociception in dynamic tissues.
  • Developed a fully implantable optogenetic system using a stretchable polyurethane tube and µ-ILEDs.
  • Used magnetic resonant coupling for wireless power transfer at 13.56 MHz.
  • Conducted in vivo experiments using a mouse model of CYP-induced acute cystitis.
  • Optogenetic activation of ArchT in sensory neurons effectively modulated nociceptive signaling.
  • Behavioral changes in a place preference assay indicated successful modulation of pain responses.
  • The implant showed good biocompatibility, avoiding fibrotic encapsulation during an 8-day period.

Cite This Study

Joo et al. (2026) studied this question.

synapsesocial.com/papers/69e5c2d003c2939914028d4fhttps://doi.org/10.1016/j.eng.2026.03.020
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