Delivery with epidural anesthesia in women with hypertensive disorder of pregnancy reduced serum TNF-α and IL-6 levels and stabilized hemodynamic parameters compared to conventional delivery (P<0.05).
Cohort (n=100)
No
Does delivery with epidural anesthesia improve inflammatory factors and hemodynamics in pregnant women with hypertensive disorder of pregnancy compared to conventional delivery?
Epidural anesthesia during delivery in women with gestational hypertension reduces inflammatory markers and stabilizes hemodynamics compared to conventional delivery.
p-value: p=<0.05
Objective: To analyze the changes in serum inflammatory factors and hemodynamics in women with hypertensive disorder of pregnancy (HDCP) who undergo delivery with epidural anesthesia. Methods: A total of 100 HDCP pregnant women were admitted to our hospital from June 2021 to December 2023 and divided into a control group (conventional delivery, i.e., vaginal delivery without analgesia) and a painless group (delivery with epidural anesthesia, i.e., continuous epidural analgesia), with 50 cases in each group. The levels of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as hemodynamic parameters including heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO), were measured and compared between the two groups at the following time points: pre-analgesia (T1), full cervical dilation (T2), fetal delivery (T3), and 24 hours postpartum (T4). Maternal and neonatal outcomes were also compared between the two groups. Results: The painless group had shorter first, second, and third stages of labor and colostrum time than the control group, and the 1 min Apgar score was higher than that of the control group (P < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (P < 0.05). The TNF-α and IL-6 levels in T2, T3, and T4 in the painless group were lower than those in the control group (P < 0.05). The fluctuation range of MAP, HR, and CO levels in T2, T3, and T4 in the painless group was smaller than that in the control group (P < 0.05) Conclusion: Delivery with epidural anesthesia for HDCP mothers can reduce perinatal inflammatory factor levels and stabilize hemodynamic parameters.
Chen et al. (Sat,) conducted a cohort in Hypertensive disorder of pregnancy (HDCP) (n=100). Delivery with epidural anesthesia (continuous epidural analgesia) vs. Conventional delivery (vaginal delivery without analgesia) was evaluated on Levels of serum TNF-α and IL-6, and hemodynamic parameters (HR, MAP, CO) (p=<0.05). Delivery with epidural anesthesia in women with hypertensive disorder of pregnancy reduced serum TNF-α and IL-6 levels and stabilized hemodynamic parameters compared to conventional delivery (P<0.05).
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