What question did this study set out to answer?

To present a rare case of solid pseudopapillary neoplasm in a male patient and discuss the diagnostic and management challenges.

April 20, 2026Open Access

An Uncommon Presentation of a Solid Pseudopapillary Neoplasm in a Male Patient: Diagnostic Challenges and Multidisciplinary Management of a Pancreatic Tail Mass

RSRana ShalabyHamad Medical Corporation KRKhadija Jaffar KI RadwaniHamad Medical Corporation SSSarah SayedHamad Medical Corporation

Key Points

To present a rare case of solid pseudopapillary neoplasm in a male patient and discuss the diagnostic and management challenges.
Case report of a 37-year-old male with a pancreatic tail mass
Imaging utilized MRI and PET scans
Histopathological evaluation confirmed the diagnosis of SPN
Surgical intervention involved robotic distal pancreatectomy with splenectomy
Diagnosis confirmed as solid pseudopapillary neoplasm through imaging and histopathology
Successful R0 resection with no nodal involvement
Highlights the role of multidisciplinary management in atypical cases

Abstract

Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that typically affects young women and has a low malignant potential. We report the case of a 37-year-old man who was being investigated for secondary hypertension when imaging revealed a pancreatic tail mass. Radiological findings suggested a differential diagnosis including SPN, cystic adenocarcinoma, or a mesenchymal tumor. Further evaluation with MRI, PET, and histopathology confirmed the diagnosis of SPN. The patient underwent successful robotic distal pancreatectomy with splenectomy and was found to have an R0 resection with no nodal involvement. This case highlights the importance of a multidisciplinary approach and maintaining a broad differential diagnosis, even in atypical patient populations.

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