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April 20, 2026Liver International0 citationsOpen Access

Effects of GLP ‐1 Receptor Agonists on Muscle Mass, Strength, and Quality in MASLD : A Systematic Review

FIFernando Iorra TJTanya JayakarImperial College London MYMichael YeeSt Mary's Hospital

Key Points

To evaluate the impact of GLP-1 receptor agonists on muscle mass, strength, and quality in individuals with MASLD.
Conducted a systematic review of existing literature
Focused on adults diagnosed with MASLD
Analyzed effects of GLP-1 receptor agonist therapy on muscle-related outcomes
No clinically meaningful loss of muscle mass reported
Strength levels remained stable during therapy
Early data suggests potential improvements in muscle quality

Abstract

Current evidence suggests that GLP-1RA therapy is not associated with clinically meaningful loss of muscle mass or strength in adults with MASLD, with early data indicating possible improvements in muscle quality.

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