Molecular mechanisms of RYRY therapy for the improvement of bipolar disorder: TCM network pharmacology and molecular docking studies

AbstractBipolar disorder is a significant mental illness characterized by mood swings. Traditional Chinese medicine has been considered a potential method for treating mental illnesses, including bipolar disorder, due to the side effects of conventional drugs and poor patient compliance. Currently, the primary TCM approach for treating mania is RYRY therapy. In this study, we identified the targets of RYRY therapy and bipolar disorder through database searches, constructed a “TCM component–BD target” network, analyzed protein–protein interactions, and performed GO/KEGG enrichment and molecular docking. The results suggest that RYRY therapy may influence bipolar disorder through targets including IL6, FOS, AKT1, and MYC, with potential involvement of cardiovascular-related processes and the IL-17 signaling pathway. These findings provide candidate molecular targets and pathways for further investigation of RYRY therapy in bipolar disorder.Note: This manuscript is a preprint and has not been peer reviewed.