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This review highlights the dual nature of Didymella species in agriculture and medicine, suggesting implications for management practices.
As members of the Didymellaceae family within the Pleosporales order of fungi, species of the genus Didymella are notable for their global distribution. This genus includes plant pathogens, endophytes, and saprobes, as well as strains that are either harmful to human health or have potential applications in disease treatment. Therefore, Didymella species present a complex duality for both plants and humans. However, research on this genus remains limited and lacks a comprehensive, systematic investigation. This review article introduces key members of the genus Didymella that cause plant diseases, promote plant growth, impact human health, or offer therapeutic potential for human diseases. It discusses the genomics and key genes of the genus, highlighting important metabolic substances associated with Didymella that exhibit inhibitory effects on plant pathogens and demonstrate cytotoxic activity against human cancer cells. Building on the mechanisms of host-pathogen interactions, the article addresses both host resistance and virulence factors affecting plant hosts. Furthermore, it reviews pathogen detection methods within the genus Didymella, the epidemiology of crop diseases, the antifungal activity for the genus Didymella, and the associated inhibitory mechanisms. Lastly, it explores integrated disease management strategies, with a focus on resistant cultivars and agronomic practices.
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Zhang et al. (2026) studied this question.
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