Abstract Background Clinical and radiographic models predict incidental meningioma growth, but their molecular architecture is unknown. Methods We analyzed serial magnetic resonance imaging, IMPACT groups (Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests), targeted gene expression, DNA methylation, and copy number (CNA) profiling of 238 consecutive incidental meningiomas from a single neurosurgical center. Results The cohort was 81% female, with median age of 59 years at detection, and median tumor volume of 3.83 cm³. Symptoms developed in 15.5%; 93.7% were treated (median time-to-treatment 1.06 years), with 5% recurrence. IMPACT groups stratified treatment-free (p 0.0001) and symptom-free survival (p = 0.0007). Most meningiomas were molecularly low risk, although those from the Hypermitotic DNA methylation group had higher IMPACT scores (p = 0.0020). Incidental meningiomas had distinct CNA and gene expression patterns and favorable outcomes compared to 1,434 non-incidental meningiomas. Conclusions These findings support surveillance for most incidental meningiomas, but early treatment may improve outcomes for molecularly higher risk cases.
Nguyen et al. (2026) studied this question.