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February 6, 2023Frontiers in Cellular and Infection Microbiology49 citationsOpen Access

The monkeypox diagnosis, treatments and prevention: A review

SKSaadullah KhattakMRMohd Ahmar RaufYAYasir Ali

Key Points

  • To review current knowledge on monkeypox virus transmission, clinical presentation, diagnostic requirements, and available prevention and treatment strategies.
  • Reviewed clinical and epidemiological evidence regarding monkeypox virus transmission mechanisms and clinical manifestations.
  • Assessed laboratory diagnostic approaches and historical smallpox vaccine cross-protection data.
  • Transmission occurs predominantly via direct contact with infected animals through broken skin, scratches, or mucosal lesions, with secondary spread through respiratory exposure.
  • Clinical presentation mimics smallpox (fever, malaise, headache, back pain, distinctive rash), making laboratory testing necessary for definitive diagnosis.
  • No specific treatment is approved for human infection, and population susceptibility has risen steadily since routine smallpox vaccination was discontinued in the 1980s.

Abstract

The world is currently dealing with a second viral outbreak, monkeypox, which has the potential to become an epidemic after the COVID-19 pandemic. People who reside in or close to forest might be exposed indirectly or at a low level, resulting in subclinical disease. However, the disease has lately emerged in shipped African wild mice in the United States. Smallpox can cause similar signs and symptoms to monkeypox, such as malaise, fever, flu-like signs, headache, distinctive rash, and back pain. Because Smallpox has been eliminated, similar symptoms in a monkeypox endemic zone should be treated cautiously. Monkeypox is transmitted to humans primarily via interaction with diseased animals. Infection through inoculation via interaction with skin or scratches and mucosal lesions on the animals is conceivable significantly once the skin barrier is disrupted by scratches, bites, or other disturbances or trauma. Even though it is clinically unclear from other pox-like infections, laboratory diagnosis is essential. There is no approved treatment for human monkeypox virus infection, however, smallpox vaccination can defend counter to the disease. Human sensitivity to monkeypox virus infection has grown after mass vaccination was discontinued in the 1980s. Infection may be prevented by reducing interaction with sick patients or animals and reducing respiratory exposure among people who are infected.

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Cite This Study

Khattak et al. (2023) studied this question.

synapsesocial.com/papers/69e5f5c562acec12c37f8ad5https://doi.org/10.3389/fcimb.2022.1088471
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