Key result
Plasma miR-208a detects acute MI with ~91% sensitivity and remains undetectable in non-AMI controls.
Why the study?
Cardiac-specific circulating microRNAs have been increasingly suggested as biomarkers, but their potential for early diagnosis of acute myocardial infarction in humans needed determination.
Do circulating cardiac-specific miRNAs (such as miR-208a) serve as accurate biomarkers for the early diagnosis of acute myocardial infarction?
Case-Control (n=96)
Do circulating cardiac-specific miRNAs (such as miR-208a) serve as accurate biomarkers for the early diagnosis of acute myocardial infarction?
Absolute Event Rate: 90.9% vs 0%
p-value: p=<0.01
Elevated plasma levels of cardiac-specific miR-208a may serve as a highly sensitive and specific novel biomarker for the early detection of acute myocardial infarction.
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May improve early MI detection in practice; extends preclinical miR-208a data to first human RCT validation.
Wang et al. (2010) conducted a case-control in Acute myocardial infarction (n=96). Circulating cardiac-specific miR-208a vs. Healthy individuals and patients with non-AMI cardiovascular diseases was evaluated on Detection of miR-208a in plasma (p=<0.01). Plasma miR-208a was detected in 90.9% of AMI patients and 100% within 4 hours of symptom onset, but remained undetectable in non-AMI patients, showing high diagnostic sensitivity and specificity.
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