Why the study?
Does the McMahon score improve the early and specific prediction of AKI in patients with rhabdomyolysis compared to creatine kinase?
Does the McMahon score improve the early and specific prediction of AKI in patients with rhabdomyolysis compared to creatine kinase?
The McMahon score is a superior, earlier predictor for AKI risk in rhabdomyolysis compared to creatine kinase, helping to identify patients who may benefit from high-volume fluid resuscitation.
May aid earlier AKI risk stratification in rhabdomyolysis; hypothesis-generating and requires prospective validation before guiding resuscitation.
Creatine kinase is not a specific or early predictor of AKI in patients with rhabdomyolysis. Although a PEAK creatine kinase of at least 5000 Ul has sensitivity acceptable for screening purposes, this is often a delayed finding. A McMahon score of at least 6 calculated on admission allows for a more sensitive, specific and timely identification of patients who may benefit from high-volume fluid resuscitation.
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Simpson et al. (2016) studied this question.
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