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This research investigates the effects of protocatechuic acid (PCA) and quercetin (Que) on ETEC-induced intestinal inflammation.

January 31, 2023Open Access

Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways

KXKan XiaoWuhan Polytechnic University MZMohan ZhouWuhan Polytechnic University QLQingqing LvThird Affiliated Hospital of Zhengzhou University

Key Points

This research investigates the effects of protocatechuic acid (PCA) and quercetin (Que) on ETEC-induced intestinal inflammation.
Examined IPEC-1 cells subjected to ETEC, assessing the impact of PCA and Que on cellular inflammation and injury.
Focused on the inhibition of necroptosis and pyroptosis signaling pathways as therapeutic mechanisms.
PCA and Que significantly reduced markers of inflammation in ETEC-treated IPEC-1 cells.
Both compounds inhibited key events in necroptosis and pyroptosis, promoting cell survival and reducing injury.

Abstract

In general, our data suggest that PCA and Que are capable of attenuating ETEC-caused intestinal inflammation and damage via inhibiting necroptosis and pyroptosis signaling pathways.

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