What question did this study set out to answer?

This study aims to analyze the cytotoxic effects of Piper betle leaf extract on HER2+ breast cancer cells and understand the involved mechanisms.

Qualitative Analysis and Cytotoxic Activity of Ethanolic Extract of Piper betle Linn.Leaves: Induction of Apoptosis, Cell Cycle Arrest, and Caspase-3/7 Activation inHER2+ AU565 Breast Cancer Cell Line

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Qualitative analysis reveals that Piper betle extract induces apoptosis in HER2+ breast cancer cells, suggesting new treatment avenues.

This study aims to analyze the cytotoxic effects of Piper betle leaf extract on HER2+ breast cancer cells and understand the involved mechanisms.
Used MTT assay to assess cell viability.
Employed Annexin V and caspase-3/7 assays to detect apoptosis.
Identified bioactive compounds using LC-MS and GC-MS techniques.
Piper betle extract significantly inhibited the proliferation of HER2+ breast cancer cells.
Induced cell cycle arrest and apoptosis were confirmed through increased apoptotic gene expression.
Activation of caspase-3/7 was observed, leading to cell death.

Fayyaz et al. (2026) studied this question.

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