Neuroimaging study reveals antidepressant treatment alters limbic and prefrontal responses in major depression, suggesting fMRI as a biomarker for treatment response.
Antidepressant treatment reduces left limbic, subcortical, and neocortical capacity for activation in depressed subjects and increases the dynamic range of the left prefrontal cortex. Changes in anterior cingulate function associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response.
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Fu et al. (2004) studied this question.
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