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Synapse
September 1, 2004Archives of General Psychiatry785 citationsOpen Access

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment

CFCynthia H.Y. FuSWSteven WilliamsACAnthony J. Cleare

Key Points

  • To investigate the effects of antidepressant treatment on regional brain activation in response to sad faces and determine if fMRI can serve as a marker of clinical response in major depression.
  • Measured neural activation in depressed subjects using functional magnetic resonance imaging (fMRI) during emotional face processing.
  • Evaluated functional changes in left limbic, subcortical, neocortical, and prefrontal brain regions following antidepressant therapy.
  • Antidepressant treatment reduced activation capacity across left limbic, subcortical, and neocortical regions in depressed subjects.
  • Treatment increased the dynamic functional range within the left prefrontal cortex.
  • Functional alterations in the anterior cingulate were directly associated with symptomatic improvement.

Abstract

Antidepressant treatment reduces left limbic, subcortical, and neocortical capacity for activation in depressed subjects and increases the dynamic range of the left prefrontal cortex. Changes in anterior cingulate function associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response.

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Cite This Study

Fu et al. (2004) studied this question.

synapsesocial.com/papers/69e8482f27a53e5314123f30https://doi.org/10.1001/archpsyc.61.9.877
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