Demonstrates magnesium ion promotes osteogenesis and angiogenesis in mesenchymal stem cells, suggesting a pathway for bone repair materials.
This study confirms that Mg²⁺ synergistically promotes osteogenic differentiation, migration of BMSCs, and angiogenesis of vascular endothelial cells by activating the PI3K-AKT-mTOR pathway. By adopting the "activation-inhibition-reversal" experimental framework and conducting in vitro and in vivo validations, the critical upstream role of PI3K and the downstream effector function of mTOR were established. These findings reveal a unified mechanism by which Mg²⁺ coordinates bone regeneration via a single signaling pathway, providing a theoretical foundation for developing smart Mg-based bone repair materials targeting this pathway.
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Huang et al. (2026) studied this question.
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