From fibrosis to thrombosis: a systematic review and meta-analysis of venous thromboembolism risk in interstitial lung disease

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Key Points

This research aims to quantify the risk of venous thromboembolism (VTE) in patients with interstitial lung disease (ILD) compared to controls.
Conducted a systematic review and meta-analysis of observational studies.
Searched databases including MEDLINE, EMBASE, and Cochrane for relevant studies up to January 2026.
Used the Newcastle-Ottawa Scale to assess study quality and employed random-effects meta-analyses for VTE risk evaluation.
Included nine studies with 7,892 ILD patients from six countries.
ILD is linked to a significantly elevated VTE risk with a pooled relative risk of 3.04.
Particularly high risk for pulmonary embolism was observed among ILD patients.

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Systematic review quantifies venous thromboembolism risk in interstitial lung disease, indicating necessary preventive measures.

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Srivali et al. (2026) studied this question.

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