Highlights show plasma cell clustering in APRIL-rich niches, indicating survival mechanisms for immune cells.
Receptor requirements for plasma cell survival and persistence. Plasma cells cluster in APRIL-rich "niches" in effector tissue. APRIL and BAFF are secreted by accessory cells and require TACI, but not BCMA, to persist. APRIL is additionally bound by CD138, potentiating survival signaling and increasing lifespan potential.
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Karaviotis et al. (2026) studied this question.
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