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April 22, 2026Cureus0 citationsOpen Access

Review of Topical Corticosteroid Withdrawal: Addiction or Side Effects?

An Updated Systematic Review of Topical Corticosteroid Withdrawal (TCSW): Steroid Addiction or Adverse Drug Effect?

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Authors

HCHunjung ChoiUniversity of MissouriMOMaria OrbeUniversity of MissouriSESahla EsamUniversity of Missouri

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Overview

This systematic review investigates the effects of topical corticosteroid withdrawal in women with atopic dermatitis, suggesting a need for better diagnosis and management strategies.

Key Points

  • This review seeks to update findings on the phenomenon of topical corticosteroid withdrawal (TCSW) and its implications.
  • Conducted a systematic search in Ovid MEDLINE, PubMed, and the Cochrane Library from October 2020 to June 2024.
  • Included analysis of seven studies, comprising five case reports, one case series, and one qualitative survey.
  • TCSW predominantly occurs in adult women (90%) using TCS for atopic dermatitis (99.5%).
  • Common symptoms are burning (89.8%), itching (85.6%), and skin hypersensitivity (82.3%).
  • TCSW is more common in women using high-potency TCS long-term on the face.

Cite This Study

Choi et al. (2026) studied this question.

synapsesocial.com/papers/69e864c46e0dea528dde96f7https://doi.org/10.7759/cureus.107365
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