Alpha-lipoic acid preserves uterine and ovarian integrity in streptozotocin-induced diabetic rats via modulation of TGF-β and HSP70 pathways

Erson Aksu; Oytun Erbaş

doi:10.1080/09513590.2026.2660420

April 19, 2026Gynecological EndocrinologyOpen Access

Alpha-lipoic acid preserves uterine and ovarian integrity in streptozotocin-induced diabetic rats via modulation of TGF-β and HSP70 pathways

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Key Points

The study aims to explore the protective effects of alpha-lipoic acid on diabetic rat reproductive tissues.
Utilized a diabetic rat model induced by streptozotocin.
Administered alpha-lipoic acid to assess its effects on uterine and ovarian health.
Analyzed molecular pathways involving TGF-β and HSP70.
Alpha-lipoic acid demonstrated antifibrotic effects in uterine and ovarian tissues.
Significant modulation of TGF-β and HSP70 pathways was observed.
Reproductive tissue integrity was preserved compared to untreated diabetic rats.

Implication

Intervention demonstrates preservation of reproductive tissue health in diabetic rats, suggesting therapeutic potential.

Abstract

ALA exerts antifibrotic and cytoprotective effects in diabetic reproductive tissues, mitigating uterine and ovarian damage through modulation of TGF-β and HSP70 pathways.

Discussion

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Cite This Study

Aksu et al. (2026) studied this question.

synapsesocial.com/papers/69e864c46e0dea528dde9707 https://doi.org/10.1080/09513590.2026.2660420

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Alpha-lipoic acid preserves uterine and ovarian integrity in streptozotocin-induced diabetic rats via modulation of TGF-β and HSP70 pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Alpha-lipoic acid preserves uterine and ovarian integrity in streptozotocin-induced diabetic rats via modulation of TGF-β and HSP70 pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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