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April 22, 2026Annals of Medicine0 citationsOpen Access

Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson’s disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies

SMSamwel Sylvester MsigwaWenzhou Medical University MMMaiko Charles MkwambeWuhan University QYQiuyan YuWenzhou Medical University

Key Points

This research aims to compare oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson’s disease and Type 2 diabetes mellitus.
Conducted a systematic review and meta-analysis of human studies
Evaluated biomarker levels in both disorders
Identified distinct profiles of biomarkers between conditions
Both F2-isoprostanes and 8-OHdG are elevated in Type 2 diabetes mellitus, but only 8-OHdG is elevated in Parkinson’s disease.
The findings suggest a potential role for 8-OHdG in understanding the comorbidity between Parkinson’s disease and Type 2 diabetes mellitus.
Recommendations for future research include standardized assays and longitudinal studies to explore mechanisms.

Abstract

Distinct profiles - both markers elevated in T2DM but only 8-OHdG in PD - underscore 8-OHdG's potential in PD-T2DM comorbidity. Future research should focus on standardized assays, multi-compartmental or multi-modal sampling, and longitudinal studies to clarify mechanisms and therapeutic targets.

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