A base‐catalyzed and elemental sulfur‐promoted decarboxylative insertion of a CN motif of isothiocyanates into an isatin ring to construct quinazoline‐2,4(1 H ,3 H )‐dithione has been described. This approach starts from easily available isatins, isothiocyanates, and sulfur, affording a series of structurally valuable heterocycles in satisfactory yields under mild conditions. Mechanism studies indicate that a base is essential to mediate the ring‐opening and thio‐Baeyer–Villiger rearrangement of isatin ring to pave the way for subsequent isothiocyanate insertion.
Nguyen et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: