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Generates a new induced pluripotent stem cell line in a healthy child, suggesting potential for disease modeling.
In this study, a healthy iPSC line SDQLCHi087-A was successfully generated by reprogramming from peripheral blood mononuclear cells using integration-free episomal plasmids. The iPSC line presented a normal karyotype, expressed high levels of pluripotent markers, and exhibited the ability to differentiate to three germ layers in vitro. The cell line serves as a valuable control for studies of molecular pathogenesis and the development of disease models.
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Lin et al. (2026) studied this question.
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