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This analysis aims to investigate the nucleotide variants of the TP53 gene in breast cancer patients and assess their impact on protein function.

Analysis of TP53 gene in breast cancer and comparison with the canine counterparts

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This analysis aims to investigate the nucleotide variants of the TP53 gene in breast cancer patients and assess their impact on protein function.
Blood samples collected from ten breast cancer patients in Punjab, Pakistan.
DNA extracted and sequenced, focusing on specific TP53 regions.
Bioinformatics tools used for sequence analysis and protein structure modeling.
Identified multiple genetic variations in the TP53 gene, including a notable cytosine deletion causing a frameshift mutation.
Several intron variants detected, indicating potential effects on gene regulation and splicing.
Highlighted the need for larger studies to fully understand these mutations' implications in breast cancer.

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Analysis investigates TP53 gene variants in breast cancer patients, suggesting potential implications for treatment.

Zahra et al. (2026) studied this question.

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