Experimental findings demonstrate that inhibiting transglutaminase 2 enhances neurological outcomes in mice after traumatic brain injury, suggesting a therapeutic strategy.
TGM2 is a key molecule affecting the BBB after TBI. Inhibition of TGM2 can alleviate the blood-brain barrier and neurological deficits after TBI, acting through the IL-17-MMP-9 axis.
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Yang et al. (2026) studied this question.
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