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April 22, 2026Journal of Affective DisordersOpen Access

An intensive longitudinal study on interpretation issues with the PHQ instructions

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Authors

LSLennart SeizerFriedrich-Alexander-Universität Erlangen-NürnbergGSGünter SchiepekParacelsus Medical University

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Implication

Intensive longitudinal study examines PHQ-9 scores in depressed patients, suggesting reliance on symptom frequency and burden.

Key Points

  • This research aims to investigate whether PHQ-9 scores correlate more strongly with symptom frequency or perceived burden in depressed individuals.
  • Conducted an intensive longitudinal study over 236 weeks involving 23 depressed patients.
  • Patients reported daily symptoms and burden across 1652 days and completed weekly PHQ-9 assessments.
  • Utilized mixed-effects models to analyze within- and between-person effects.
  • Weekly PHQ-9 scores aligned with both daily symptom frequency and perceived burden.
  • In separate analyses, increases in frequency or burden were associated with higher PHQ-9 scores.
  • Variability among patients indicated differences in the reflection of frequency versus burden by PHQ-9 scores.

Cite This Study

Seizer et al. (2026) studied this question.

synapsesocial.com/papers/69e866416e0dea528ddea9e2https://doi.org/10.1016/j.jad.2026.121826
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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