Research demonstrates regioselective C-H allylation of tetrahydroquinolines and indolines, suggesting a new method for synthesizing derivatives.
A regioselective C-H allylation process was established for both tetrahydroquinolines (THQs) 2a-2d and indolines 2e-2n with vinyl benzoxazinanones 1a-1g, affording the corresponding C6- and C5-allylated products, respectively. As a result, a series of THQ and indoline derivatives 3a-3n and 4a-4q were synthesized with excellent regioselectivities and E/Z ratios (>19:1).
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Liu et al. (2026) studied this question.
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