Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK / PINK1 ‐Mediated Mitophagy

Kezhu Chen; Xiangyang Deng; Jun Zeng; 孙宝业; Jingyu Yu; TT Li; Junjie Zhong; Pengjie Hong; Peng Wang; Fengshi Li; Quan Zhang; Junwei Ren; Qisheng Tang; Tongming Zhu; J ZHU

doi:10.1002/cns.70881

April 1, 2026CNS Neuroscience & TherapeuticsOpen Access

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK / PINK1 ‐Mediated Mitophagy

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Key Points

This research focuses on the impact of inhibiting microglial TRPV1 on brain injury post-intracerebral hemorrhage.
Inhibition of microglial TRPV1 in a model of intracerebral hemorrhage.
Evaluation of inflammation and mitophagy changes after TRPV1 inhibition.
Inhibition of TRPV1 reduces inflammation in the brain after injury.
TRPV1 blockade positively affects mitophagy processes post-intracerebral hemorrhage.

Implication

Targeted inhibition of microglial TRPV1 improves outcomes after intracerebral hemorrhage, suggesting a new therapeutic approach.

Abstract

TRPV1 activation in microglia exacerbates ICH injury by promoting inflammation and disruptive mitophagy. Targeted inhibition of microglial TRPV1 represents a promising therapeutic strategy for ICH.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69e866ad6e0dea528ddeb00e https://doi.org/10.1002/cns.70881

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Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK / PINK1 ‐Mediated Mitophagy

Key Points

Implication

Abstract

Discussion

Cite This Study

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK / PINK1 ‐Mediated Mitophagy

Key Points

Implication

Abstract

Discussion

Cite This Study

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