April 22, 2026Journal of the American Heart Association0 citationsOpen Access
View Full PaperAssociation Between Nerve Growth Factor and Clinical Stroke and Covert Brain Infarcts: The FHS
Key Points
- To examine the relationship between serum levels of nerve growth factor and the risk of stroke and brain infarcts in late midlife.
- Observational study design using data from the Framingham Heart Study (FHS).
- Assessment of serum nerve growth factor levels in participants.
- Analysis of stroke incidence and covert brain infarcts over time.
- Higher levels of serum nerve growth factor were associated with a reduced risk of clinically overt stroke.
- Serum NGF levels correlated with a lower occurrence of covert brain infarcts, indicating a protective effect.
Abstract
Higher serum NGF in late midlife demonstrates a protective association with future risk of silent and clinically overt stroke.