⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 17, 2018Journal of Experimental & Clinical Cancer ResearchOpen Access

Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

Xiudong Guan Lanxin Luo Gulnaz Begum Gary Kohanbash Qingkun Song Aparna Rao Nduka Amankulor Baoshan Sun Dandan Sun Wang Jia

View Full Paper

Ask AI

Bookmark

Share

Abstract

Our findings strongly suggest that NHE1 protein emerges as a marker for tumorigenesis and prognosis in glioma. Blocking NHE1 protein is a novel strategy for adjuvant anti-cancer therapies.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Guan et al. (2018) studied this question.

synapsesocial.com/papers/69e88b60c8a7fe3f9324b7e8 https://doi.org/10.1186/s13046-018-0923-z

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation2009 · 16,147 citations
2Drug repurposing for the treatment of glioblastoma multiformeOriginal Research · 2017 · 86 citations
3Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesOriginal Research · 2002 · 1,749 citations
4Voltage‐gated sodium channel Nav1.7 promotes gastric cancer progression through MACC1‐mediated upregulation of NHE1Original Research · 2016 · 86 citations
5Na+/H+exchanger 1, Na+/Ca2+exchanger 1 and calmodulin complex regulates interleukin 6-mediated cellular behavior of human hepatocellular carcinomaOriginal Research · 2016 · 37 citations

More related papers

Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity2012
CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion2004
Value of pH regulators in the diagnosis, prognosis and treatment of cancer2017

More from Journal of Experimental & Clinical Cancer Research

ERG inhibition selectively sensitizes ERG-positive prostate cancer to radiation through DNA repair vulnerabilities and enhances response to androgen receptor inhibitorsFri,
Tetrandrine stabilizes NCOA4 to promote ferritinophagy-mediated ferroptosis and enhance antitumor immunity in NSCLCThu,