What question did this study set out to answer?

Evaluate the long-term impact of intensive lifestyle modifications on the progression or reversal of coronary atherosclerosis.

December 16, 1998JAMA

Intensive Lifestyle Changes for Reversal of Coronary Heart Disease

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Why the study?

Do intensive lifestyle changes improve regression of coronary atherosclerosis and reduce cardiac events in patients with coronary heart disease?

Population

Patients with coronary heart disease

Comparison

Intensive lifestyle changes vs Control group

Follow-up

5 years

Authors

Hypothesis-generating for intensive lifestyle changes in CHD; larger randomized trials needed before clinical adoption.

Evaluate the long-term impact of intensive lifestyle modifications on the progression or reversal of coronary atherosclerosis.
Followed an experimental group receiving an intensive lifestyle intervention alongside a standard-care control group over 5 years.
Tracked coronary atherosclerosis regression and progression at 1-year and 5-year intervals, alongside the incidence of cardiac events.
Coronary atherosclerosis showed greater regression after 5 years than after 1 year in the experimental group.
The control group showed continuous progression of coronary atherosclerosis and sustained more than twice as many cardiac events.

Do intensive lifestyle changes improve regression of coronary atherosclerosis and reduce cardiac events in patients with coronary heart disease?

Population

Patients with coronary heart disease

Intervention

Intensive lifestyle changes

Comparator

Control group

Outcome

Regression of coronary atherosclerosis and cardiac eventssurrogate

Intensive lifestyle changes over 5 years are associated with regression of coronary atherosclerosis and a reduction in cardiac events.

Dean Ornish (1998) studied this question.

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