Development and internal validation of the PROFIT and POSITIVE prognostic nomograms for patients undergoing VA-ECMO therapy

Figures

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  Fig. 1. Study flowchart. CSECLS Chinese society of extra corporeal life support, ECMO extracorporeal membrane oxygenation, VA-ECMO venoarterial ECMO.

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  Fig. 2. Nomograms for the prediction of VA-ECMO mortality. (A) The nomogram PROFIT was conducted to predict mortality during VA-ECMO assistance. (B) The nomogram POSITIVE was conducted to predict in-hospital mortality in patients treated with VA-ECMO. PROFIT PROFIT PRediction mOdel oF mortalIty during VA-ECMO supporT, POSITIVE Prediction mOdel of in-hoSpItal morTalIty in VA-ECMO support patients, VA-ECMO venoarterial extracorporeal membrane oxygenation.

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  Fig. 3. ROC curves of the nomograms in the derivation cohort. (A) The ROC curves of the nomogram PROFIT for predicting 1 week, 2 weeks and 4 weeks mortality during VA-ECMO assistance had better discrimination properties than the SAVE score. (B) The ROC curves of the nomogram POSITIVE for predicting 1 month, 2 months and 3 months in-hospital mortality had better discrimination properties than the SAVE score. ROC receiver operator characteristic, PROFIT PROFIT PRediction mOdel oF mortalIty during VA-ECMO supporT, POSITIVE Prediction mOdel of in-hoSpItal morTalIty in VA-ECMO support patients, VA-ECMO venoarterial extracorporeal membrane oxygenation.

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  Fig. 4. Calibration curves of the nomograms prediction in the derivation cohort and validation cohort. (A) Calibration curve of the nomogram PROFIT of predicting 1-week mortality during VA-ECMO assistance in the derivation cohort. (B) Calibration curve of the nomogram POSITIVE of predicting 1-month in-hospital mortality in the derivation cohort. (C) Calibration curve of the nomogram PROFIT of predicting 1-week mortality during VA-ECMO assistance in the validation cohort. (D) Calibration curve of the nomogram POSITIVE prediction of predicting 1-month in-hospital mortality in the validation cohort. PROFIT PROFIT PRediction mOdel oF mortalIty during VA-ECMO supporT, POSITIVE Prediction mOdel of in-hoSpItal morTalIty in VA-ECMO support patients, VA-ECMO venoarterial extracorporeal membrane oxygenation.

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  Fig. 5. Kaplan-Meier (K-M) survival curves of patients stratified by the nomograms in the derivation cohort and validation cohort. (A) K-M survival curve of patients stratified by the nomogram PROFIT in the derivation cohort. (B) K-M survival curve of patients stratified by the nomogram POSITIVE in the derivation cohort. (C) K-M survival curve of patients stratified by the nomogram PROFIT in the validation cohort. (D) K-M survival curve of patients stratified by the nomogram POSITIVE in the validation cohort. PROFIT PROFIT PRediction mOdel oF mortalIty during VA-ECMO supporT, POSITIVE Prediction mOdel of in-hoSpItal morTalIty in VA-ECMO support patients.