Is the presence of free spike antigen associated with the development of post-COVID-19 mRNA vaccine myocarditis in adolescents and young adults?
The detection of free circulating spike protein in patients with post-COVID-19 mRNA vaccine myocarditis provides insight into its potential underlying pathophysiological cause.
Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine-induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.
Yonker et al. (Wed,) studied this question.