Why the study?
Self-amplifying mRNA vaccines could provide another option for Covid-19 prevention if demonstrated to be safe and immunogenic.
Does the ARCT-021 self-amplifying mRNA vaccine demonstrate safety and immunogenicity compared to placebo in healthy adults?
Population
Healthy young and older adults (N = 42 in Phase 1, N = 64 in Phase 2)
Comparison
ARCT-021 vaccine vs placebo
Design
Phase 1/2 randomized, double-blinded, placebo-controlled trial
Authors
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ARCT-021 shows favorable safety and immunogenicity in adults; extends self-amplifying mRNA platform evaluation for COVID-19.
Does the ARCT-021 self-amplifying mRNA vaccine demonstrate safety and immunogenicity compared to placebo in healthy adults?
The self-amplifying mRNA vaccine ARCT-021 is safe, well-tolerated, and immunogenic in healthy adults, supporting its further development for Covid-19 prevention.
Low et al. (2022) studied this question.
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