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April 23, 2026JACC Case ReportsOpen Access

Cardioneuroablation Restoring Atrioventricular Conduction in Brugada Syndrome

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Why the study?

Does cardioneuroablation restore atrioventricular conduction in young patients with Brugada Syndrome and functional atrioventricular block?

Population

Young patients with BrS and functional atrioventricular block

Comparison

CNA vs pacemaker implantation

Key result

Cardioneuroablation restores atrioventricular conduction in Brugada syndrome, offering a durable alternative to pacemakers for young patients with functional AV block.

Authors

FCFredy ChipaJBJosep BrugadaALAgustin Leonardo Lujan

Discussion

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Overview

Hypothesis-generating for CNA in young BrS patients with functional AV block; leaves open validation in prospective trials before adoption.

Key Points

  • To evaluate the effectiveness of cardioneuroablation in restoring atrioventricular conduction in patients with Brugada syndrome.
  • Assessing vagally mediated functional bradyarrhythmias through atropine testing.
  • Performing cardioneuroablation as an intervention for atrioventricular block.
  • CNA provided a physiological approach to restore atrioventricular conduction.
  • Patients showed a significant response to atropine testing, indicating improved cardiac function.

Structured PICO

Does cardioneuroablation restore atrioventricular conduction in young patients with Brugada Syndrome and functional atrioventricular block?

P
Population
Young patients with Brugada Syndrome (BrS) and functional atrioventricular block
I
Intervention
Cardioneuroablation (CNA)
O
Outcome
Restoration of atrioventricular conduction

Cardioneuroablation may serve as a physiological and durable alternative to pacemaker implantation for young patients with Brugada Syndrome and functional AV block.

Cite This Study

Chipa et al. (2026) studied this question. Cardioneuroablation restores atrioventricular conduction in Brugada syndrome, offering a durable alternative to pacemakers for young patients with functional AV block.

synapsesocial.com/papers/69e9b62685696592c86eade5https://doi.org/10.1016/j.jaccas.2026.107843
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